@blecap1 This is a terrible idea, and I think you should evaluate this more from a financial perspective than as an emotional decision.
You will have to pay a 10% penalty on the withdrawal in addition to the standard income tax. Note that this income is on top of the income from your job, so it will effectively be taxed at the marginal rate that you pay currently.
Homeownership comes with a lot of obligations for property tax, maintenance, mortgage, etc. that can easily eclipse the rent you are currently paying. It also makes it hard to relocate for a better job. You could find yourself in a deep financial hole if you don't have liquid assets if you lose your job or have a major emergency. (And you don't, because you'd be using those rather than your retirement fund for the down payment).
If you want to bet on the property market, consider putting your money in a REIT in your retirement account, where you will start with the extra 30% you would have given to the IRS.
Here are some numbers: assuming you make 50k/year as a single person, you pay a 22% marginal tax rate (a small amount at 24% as well). You pay an additional 10% penalty for 32%. Your 60k 403b fund is now $40800.
Additionally penalty-free distributions start at age 59.5 not 65.
Edit: I looked a bit more into the tax situation to make sure I got all my facts right. As some other commenters pointed out, if you are a first time homebuyer, you can withdraw up to $10000 penalty (but not tax) free from an IRA to buy a home. Note that the rule does not apply to 401(k)s, but you can rollover the 401(k) into an IRA first.
You'd get $7800 for that, so in total you should end up with $41800 if you wiped out your 401(k) this way.